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Comparison of system suffering from western-related conditions and system with amelioration of western-related conditions
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- This article compares a system suffering from western-related conditions and a system with amelioration of western-related conditions. One aspect of a western lifestyle is the higher intake of ω-6 PUFA, which enhances the formation of chylomicrons allowing the translocation of LPS. This leads to the activation of basolateral TLR and initiation of a pro-inflammatory response. The gut epithelium and its permeability are altered, exacerbating inflammation by allowing the translocation of more LPS, pro-inflammatory cytokines, FFA, among other luminal compounds.
- The comparison is shown in a visual representation, with the system suffering from western-related conditions depicted in red on the right, and the system with amelioration of western-related conditions depicted in orange on the left. The higher intake of ω-6 PUFA in the western lifestyle enhances the formation of chylomicrons, which allows the translocation of LPS. This results in the activation of basolateral TLR and the initiation of a pro-inflammatory response. The gut epithelium and its permeability are compromised, leading to the escalation of inflammation.
- The comparison between a system suffering from western-related conditions and a system with amelioration of western-related conditions highlights the impact of ω-6 PUFA intake. The higher intake of ω-6 PUFA enhances the formation of chylomicrons, facilitating the translocation of LPS. This triggers a pro-inflammatory response mediated by basolateral TLR activation. The gut epithelium becomes compromised, exacerbating inflammation by allowing the translocation of more LPS, pro-inflammatory cytokines, FFA, and other luminal compounds.
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