和訳をお願いしますm(。・ω・。)m
The latest study involved 40 patients infected with P. falciparum in Pailin, and another 40 in Wang Pha, in northwest Thailand2. Half of each group were given just artesunate, and the other half the dual artesunate–mefloquine therapy.
The Cambodian group took almost twice as long to clear the parasite from their body as the Thai group: 84 hours compared with 48 hours. Usually artemisinin drugs clear the parasite within three days, says Nick Day, director of the Mahidol Oxford research unit in Bangkok and co-author of the study, published in the New England Journal of Medicine.
Infection broke out again for six of the twenty patients taking just artesunate in Cambodia, compared with two patients in Thailand. With the combined therapy, it recurred in only one of the twenty cases in each group.
The World Health Organization recommends that artemisinin-based drugs be given only in combination, to delay the onset of resistance. But Day explains that the single-dose groups were crucial in their controlled study to show that there was growing resistance to artesunate, and not to mefloquine alone.
The emergence of artemisinin-resistant malaria in Cambodia is especially worrying, because previous drug-resistant strains of malaria have sprung from there. "This is a wake-up call," says Day. "We have got reduced susceptibility to the drugs in an area where we've seen resistance emerge before." Given time, the parasite will only become more resistant to the drugs, he adds.
よろしくお願いしますorz
お礼
ありがとうございました。辞書でみつからず困っていました。