論文の和訳をお願いします！

質問

まず、本文です！
１）With respect to mammalian systems, only two SNARE complexes have been described for ER-derived vesicles that fuse with the cis Golgi.
２）In one, Sec22b was the v-SNARE and syntaxin5, membrin and rBet1 were the t-SNAREs in NRK cells.
３）In the other, also using NRK cells, Ykt6 was the v-SNARE with syntaxin5, GOS28, and rBet1 as the t-SNAREs.
４）Both Ykt6 and Sec22b have been shown to have similar N-termini.
５）Because of their N-terminal extensions to the coiled-coil domains of the synaptobrevin-like SNARE motif of most v-SNAREs, these SNAREs have been called longins.
６）VAMP7, an additional member of the longin family (TI-VAMP, SYBL1), has not been described as an ER-related SNARE, but has been shown to be predominately associated with endosomes in mammals.
７）VAMP7 and Sec22b have both been shown to have a widespread tissue distribution whereas Ykt6 is predominantly found in brain in a lysosome-related compartment .

僕が今読んでいる論文はＶｅｓｓｉｃｌｅ－associated membrane protein7(VAMP7) is expressed in intestinal ERという論文の一部です

１文目ですが、ＥＲは小胞体のことで、小胞体由来の小胞がシスゴルジ体に輸送されると書かれていると思います。
２文目のＮＲＫは通常ラット腎臓のことだと思います。
特に５文目からわかりません・・synaptobrevin-like SNARE motifや、longinsなど・・。

回答No.1

noname#175206

>１）With respect to mammalian systems, only two SNARE complexes have been described for ER-derived vesicles that fuse with the cis Golgi.

「哺乳類の生体機構に関して、たった二つのSNAREタンパク質（可溶性N-エチルマレイミド感受性因子付着タンパク質受容体）複合体は、シスゴルジ（網）内で融合するER由来の小胞の面から、説明されてきた。」

>２）In one, Sec22b was the v-SNARE and syntaxin5, membrin and rBet1 were the t-SNAREs in NRK cells.

「二つのうち、一方では、Sec22b が、v-SNAREとsyntaxin5であり、membrinとrBet1が、NRK細胞内のt-SNAREsであった。」

>３）In the other, also using NRK cells, Ykt6 was the v-SNARE with syntaxin5, GOS28, and rBet1 as the t-SNAREs.

「もう一方のほうは、やはりNRK細胞を介して、Ykt6は、v-SNAREがsyntaxin5、GOS28、rBet1と共に、t-SNAREとして存在している。」

>４）Both Ykt6 and Sec22b have been shown to have similar N-termini.

「Ykt6 and Sec22bの双方共、N末端様のものを持つことが示されている。」

>５）Because of their N-terminal extensions to the coiled-coil domains of the synaptobrevin-like SNARE motif of most v-SNAREs, these SNAREs have been called longins.

「ほとんどのv-SNAREのシナプトブレビン様SNARE配列モチーフのコイルドコイルドメインへのN末端伸長のため、そうしたSNAREはLongin(s)と呼ばれてきた。」

>６）VAMP7, an additional member of the longin family (TI-VAMP, SYBL1), has not been described as an ER-related SNARE, but has been shown to be predominately associated with endosomes in mammals.

「Longin族に加わったVAMP7（別名：TI-VAMP、SYBL1）は、ER関連のSNAREとは見做されていないが、哺乳類にあるエンドゾームとの優位な関連性が示されている。」

>７）VAMP7 and Sec22b have both been shown to have a widespread tissue distribution whereas Ykt6 is predominantly found in brain in a lysosome-related compartment .

「VAMP7とSec22bは、Ykt6がリソソーム関連のコンパートメントとしての脳内に優勢的であることが見つかっているにも関わらず、どちらも広く生体内分布をしている。」

お礼

ありがとうございました！