大腸菌の遺伝子とその機能について

質問

大腸菌は遺伝子とその機能の同定がかなり進んでいると思うのですが、できるだけ多く、それらの機能についてまとめて知りたいと思っています。
そんなデータをまとめた論文ないし教科書などご存知の方がいたら教えていただきたいです。
文献は日本語でも英語でも構いません。よろしくお願いします。

回答No.1

ga111

古いですが、全配列決定の話なので、総括的なことが本文に書いてある「かも」しれません。

Science. 1997 Sep 5;277(5331):1453-74.

Comment in:
Science. 1997 Sep 5;277(5331):1432-4. Science. 1998 Mar 20;279(5368):1827.

The 4,639,221-base pair sequence of Escherichia coli K-12 is presented. Of 4288 protein-coding genes annotated, 38 percent have no attributed function. Comparison with five other sequenced microbes reveals ubiquitous as well as narrowly distributed gene families; many families of similar genes within E. coli are also evident. The largest family of paralogous proteins contains 80 ABC transporters. The genome as a whole is strikingly organized with respect to the local direction of replication; guanines, oligonucleotides possibly related to replication and recombination, and most genes are so oriented. The genome also contains insertion sequence (IS) elements, phage remnants, and many other patches of unusual composition indicating genome plasticity through horizontal transfer.